Using CompuCell3D as a Platform to Construct Multicellular Virtual Tissues to Explore the Interactions between Infection, Host Tissues and Immune Response

Multiscale, multicellular Virtual Tissue models built using modeling frameworks like CompuCell3D are versatile tools for exploring the complex interactions between intracellular signaling and gene-regulatory networks, inter-cellular signaling through contact and diffusible signals, and force generation, cell migration and shape change. Several prior speakers have discussed a variety of models of infection, immune response and drug treatment. Here, I focus on how CompuCell3D can simplify the construction of complex, extensible and reusable Virtual Tissue models. Interested members of the audience can follow along by downloading the software from (www.compucell3d.org) or run it on-line at (https://nanohub.org/resources/cc3dbase4x; usage is free but does require you to register in advance). I will also briefly discuss advances in CompuCell3D to enable it to be used in a Jupyter notebook environment and our new Mechanica software package. To learn more or to try CompuCell3D see: https://compucell3d.org/ *Contents* 0:00 - Introduction: J Glazier 9:00 - Coming Up 10:10 - James Glazier: Using CompuCell3D as a Platform to Construct Multicellular Virtual Tissues to Explore the Interactions between Infection, Host Tissues and Immune Response 48:25 - Q&A Session For the slides in this video, see: https://docs.google.com/presentation/d/1I9cfodaEmK-I4J0-BF3ieWkpibRReI61/ If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://tinyurl.com/GLIMPRINTVideos Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/