OpenVT – A Standardized Ecosystem for Virtual Tissue Simulation

We present an overview, initial progress, and plans for Open Virtual Tissues (OpenVT), a NSF-funded project that seeks to improve the ecosystem of multicellular modeling frameworks. There exist several such frameworks, covering different fundamental modeling approaches, programming languages, model specification formats, workflows, varying degrees of user support, etc. This presents challenges to new modelers who want to understand what these frameworks can do (or can't do) and also to experienced modelers who would like to "reproduce" model results using more than one framework. Indiana University leads two of the frameworks, CompuCell3D and PhysiCell (PIs Glazier and Macklin), providing a hub of initial activity: seeking shared concepts, modules, data formats/standards, and reproducibility. However, the project also includes other modeling frameworks as we want this to be a community effort. The OpenVT project kicked off with an intensive NSF I-Corps program, which we will also briefly summarize. *Contents* 00:00 - Introduction 04:35 - OpenVT – A Standardized Ecosystem for Virtual Tissue Simulation 47:10 - Questions and Discussion Moderator: Tom Helikar, PhD, University of Nebraska, Lincoln If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/