Multiscale Monte Carlo Modeling for Radiation Therapy Applications

The response of living systems to radiation results from complex interactions among physical, chemical, and biological processes across subcellular, cellular, and tissue scales. Given this complexity, computational modeling offers a powerful approach to describe and interpret these multi-scale interactions in the context of radiation therapy. To address the wide range of spatial and temporal scales, as well as the diverse mechanisms involved, we have developed a flexible framework that integrates specialized simulation tools: TOPAS-nBio for physical, chemical, and biological processes at the nanoscale; CompuCell3D for agent-based modeling of cellular and tissue-scale dynamics; and TOPAS for patient-level treatment outcome simulations. Using this framework, we focus on the development of emerging radiation therapy techniques. For instance, we investigated how tumor growth and vascular redistribution influence the preferential effects of microbeam radiotherapy on tumors versus normal tissues, with a focus on changes in tissue oxygenation. For more information see: Tumor growth and vascular redistribution contributes to the dosimetric preferential effect of microbeam radiotherapy: a Monte Carlo study, https://www.nature.com/articles/s41598-024-77415-5.pdf TOPAS-Tissue: A Framework for the Simulation of the Biological Response to Ionizing Radiation at the Multi-Cellular Level: https://www.mdpi.com/1422-0067/25/18/10061 A clustering tool for generating biological geometries for computational modeling in radiobiology: https://iopscience.iop.org/article/10.1088/1361-6560/ad7f1d/pdf *Contents* 00:00 - Introduction 08:20 - Multiscale Monte Carlo Modeling for Radiation Therapy Applications 51:05 - Questions and Discussions Moderator: James A. Glazier For the slides for this video visit: https://drive.google.com/file/d/1X93lNKdY0mYGy2wEI89g0SyVd9axCjGO/view?usp=sharing If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/