Multiscale Modeling of Human Physiology

HumMod is a model of human physiology comprising over 9000 dependent variables, and over 1500 independent parameters. It spans all major body systems, including circulatory, renal, respiratory, hepatic, gastrointestinal, neural, endocrine and muscular systems. Each system is built on one or more working hypotheses/models developed in the literature with reasonable support. These systems combine multiple tissues and their responses to hormones, metabolites, and physical forces. In the laboratory, such responses are considered under controlled circumstances. In the model, the simple mechanisms are tied together to produce feedback loops approximating the body’s own responses to physiological challenges. Current projects include: 1) simulations to understand how medical devices work and 2) simulating virtual populations for in silico clinical trials. For more details see: https://www.umc.edu/som/Departments%20and%20Offices/SOM%20Departments/Physiology/About-Us/Faculty-and-Staff/Robert_Hester_.html If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/