Modeling Innate Immune Signaling: Some Emerging Regulatory Principles

Immune cells must respond appropriately to diverse pathogens or immune stimuli. Four signaling pathways function combinatorially and dynamically to transmit information about the immune threat to nuclear immune response genes. We have developed mathematical models of the molecular networks that recapitulate their stimulus-specific signaling dynamics of the transcription factors NFκB and ISGF3. A number of circuit motifs and regulatory principles give rise to hallmark dynamic features. Their target genes decode these dynamics via molecular mechanisms that may also be accounted by mathematical models. For more details see: https://www.sciencedirect.com/science/article/pii/S1074761321003502 Chapters: 0:00 - Introduction: J Glazier 5:36 - Coming Up 6:49 - Seminar: Alexander Hoffmann: Modeling Innate Immune Signaling: Some Emerging Regulatory Principles 50:40 - Q&A Session If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/