Lessons of COVID for Science Policy and Politics

Additional articles by Phillip Ball: Shot of hope: inside the race for a coronavirus vaccine https://www.prospectmagazine.co.uk/magazine/when-will-there-be-vaccine-coronavirus-progress What you need to know about the coronavirus vaccine https://www.prospectmagazine.co.uk/magazine/what-you-need-to-know-about-the-coronavirus-vaccine The epidemiology of misinformation https://www.prospectmagazine.co.uk/science-and-technology/epidemiology-misinformation-coronavirus-covid19-conspiracy-theory Ten lessons of the Covid-19 pandemic https://www.newstatesman.com/international/coronavirus/2020/10/ten-lessons-covid-19-pandemic The silence of the chief scientist ... https://www.newstatesman.com/politics/health/2020/05/silence-chief-scientists-worrying-and-deeply-political The day that Dominic Cummings finally came clean https://www.thearticle.com/the-day-that-dominic-cummings-finally-came-clean Mr. Ball also pointed out this interesting Opinion Piece in Science: "Science journalism grows up" Deborah Blum, Science 23 Apr 2021:Vol. 372, Issue 6540, pp. 323 DOI: 10.1126/science.abj0434 Viral infection and Initiation of Thrombosis Miriam Rafailovich, Department of Materials Science, SUNY at Stony Brook. Title: . Abstract: The conformation of fibrinogen on hydrophobic surfaces is shown to initiate fibrillogenesis and non-thrombogenic clots. Even though endothelial cells are not easily infected, non-thrombogenic clots are shown to form after exposure of the cells to conditioned media from epithelial cells infected with H1N1 and OC43 encapsulated RNA viruses. Inflammatory factors secreted from infected epithelium is believed to be responsible for damage to the endothelium, initiating opening of the fibrinogen alpha-C domains initiating fibrillogenesis. Blocking the terminus of the alpha-C domains with a 12 amino acid peptide, prevents fibrinogen fiber formation, which may suppress spontaneous clot formation associated with viral infection. A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection https://www.sciencedirect.com/science/article/pii/S0092867409015657 Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia https://pubmed.ncbi.nlm.nih.gov/27041635/ Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses https://pubmed.ncbi.nlm.nih.gov/32657623/ Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2015432 Effects on Coagulation and Fibrinolysis Induced by Influenza in Mice With a Reduced Capacity to Generate Activated Protein C and a Deficiency in Plasminogen Activator Inhibitor Type 1 https://www.ahajournals.org/doi/full/10.1161/01.RES.0000250834.29108.1a Control of Anti-Thrombogenic Properties: Surface-Induced Self-Assembly of Fibrinogen Fibers https://pubs.acs.org/doi/10.1021/bm2015976 In situ conformational analysis of fibrinogen adsorbed on Si surfaces https://www.sciencedirect.com/science/article/abs/pii/S0927776505000986 If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/