Dynamics and Sensitivity of Signaling Pathways

Signaling pathways are protein networks that respond to external signals that modulate cell behavior. This is particularly the case with mammalian cells, where communication is essential for individual cells to cooperate as a cohesive unit. Genetic mutations to one or more proteins in a signaling pathway is often one of the hallmarks of uncontrolled tumor growth. As a result, proteins found in signaling networks are often considered targets for therapeutic agents. However, whether a given protein is a suitable target depends on how it communicates perturbations to the rest of the network and, ultimately, the cell's outward phenotype. In this presentation, I will describe some existing and new results in understanding how the sensitivities in a signaling network are influenced by feedback loops and how such work can lead to a better understanding of the operational characteristics of signaling pathways. Moderator: James A. Glazier, PhD, Indiana University, Bloomington For more information see: Kochen, Michael A., Steven S. Andrews, H. Steven Wiley, Song Feng, and Herbert M. Sauro. "Dynamics and sensitivity of signaling pathways." Current pathobiology reports 10, no. 2 (2022): 11-22. https://link.springer.com/article/10.1007/s40139-022-00230-y If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://tinyurl.com/GLIMPRINTVideos Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/