A Single-cell Mathematical Model of SARS-CoV-2 Induced Pyroptosis

Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokinestorm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inflammasome formation, and by extension pyroptosis, may be inhibited by certain anti-inflammatory drugs. In this study, we present a single-cell mathematical model that captures the formation of the NLRP3 inflammasome, pyroptotic cell death and responses to anti-inflammatory intervention that hinder the formation of the NLRP3 inflammasome. Our results demonstrate that an anti-inflammatory drug can delay the formation of the NLRP3 inflammasome, and thus may alter the mode of cell death from inflammatory (pyroptosis) to non-inflammatory (e.g., apoptosis). The single-cell model is further implemented at a multicellular level within a SARS-CoV-2 tissue simulator in collaboration with a multidisciplinary coalition investigating within host-dynamics of COVID-19. Moderator: James A. Glazier, PhD, Indiana University, Bloomington To learn more see: Hamis, Sara J., and Fiona R. Macfarlane. "A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention." arXiv preprint arXiv:2008.04172 (2020). https://www.aimspress.com/article/doi/10.3934/math.2021356 To view the slides in this video, visit: https://drive.google.com/file/d/13EJZhogWNX4C0iROPnED6AxDyWAvRtYR/ If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://tinyurl.com/GLIMPRINTVideos Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/